Which option is NOT a general requirement for injections?

• A. Sterile
• B. Pyrogen-free
• C. Non-sterile
• D. Particle-free if solution

Answer: (C)

Injections must be sterile, pyrogen-free, and particle-free if the preparation is a solution, because safety depends on avoiding infection, fever, and particulates in the bloodstream. Sterility ensures no microorganisms are present to cause infection or sepsis. Pyrogen-free means there are no fever-causing substances, such as endotoxins, that can trigger fever or inflammatory reactions even at very low levels. Particle-free for solutions means the liquid contains no extraneous particulates that could clog vessels or irritate tissues; if the product is a suspension, particulates are intentional, but for a true solution they must be absent. Therefore being non-sterile is not a general requirement for injections.