Which condition increases dermal absorption?

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Multiple Choice

Which condition increases dermal absorption?

Explanation:
Dermal absorption hinges on skin barrier integrity; when the barrier is compromised, absorption goes up. In eczema, the outermost layer (the stratum corneum) is disrupted by inflammation and lipid loss, creating microfissures and increasing transepidermal water loss. This weakened barrier allows more drug molecules to diffuse into the skin and even into the bloodstream, so dermal absorption is enhanced. Hyperpigmented skin doesn’t inherently signal a permeability change, and while aging can alter barrier properties, the most consistent reason absorption increases in this context is barrier disruption from eczema.

Dermal absorption hinges on skin barrier integrity; when the barrier is compromised, absorption goes up. In eczema, the outermost layer (the stratum corneum) is disrupted by inflammation and lipid loss, creating microfissures and increasing transepidermal water loss. This weakened barrier allows more drug molecules to diffuse into the skin and even into the bloodstream, so dermal absorption is enhanced. Hyperpigmented skin doesn’t inherently signal a permeability change, and while aging can alter barrier properties, the most consistent reason absorption increases in this context is barrier disruption from eczema.

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