What percentage excess should be added to compensate for loss during compounding?

• A. 5%
• B. 10%
• C. 15%
• D. 20%

Answer: (B)

Losses during weighing and transfer are common in compounding. To ensure the final product has the exact intended amount, you add some excess to the amount you weigh so that, after the anticipated loss, you end up with the target quantity. Ten percent is a standard amount used because it usually covers typical losses without overshooting too much. If you only add five percent, losses might still leave you short. Adding fifteen or twenty percent would overcompensate and could lead to too much drug in the final product and unnecessary waste. For example, needing 100 g of final product, you would weigh 110 g; after the 10% loss, you’d have the desired 100 g.