What is the maximum IM injection volume for the buttock?

• A. 5 mL
• B. 2 mL
• C. 1 mL
• D. 0.5 mL

Answer: (A)

The buttock can accommodate relatively large intramuscular volumes because the gluteus maximus is a large, well-muscled area with good absorption capacity. In adults, an IM injection into this site is typically limited to about 5 mL. Using this site up to 5 mL helps ensure the medication reaches the muscle rather than sitting in subcutaneous tissue, which would slow absorption and potentially cause more discomfort. If you need to inject into the buttock, place the needle in the upper outer quadrant to avoid underlying nerves and vessels. Smaller volumes are appropriate for other sites (like the deltoid), but the maximum for the buttock itself is 5 mL.