Systemic absorption of drugs occurs in what layer of the skin?

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Multiple Choice

Systemic absorption of drugs occurs in what layer of the skin?

Explanation:
Systemic absorption requires the drug to reach the skin’s blood vessels. The stratum corneum is the main barrier to crossing the skin, and the epidermis itself is largely avascular. The dermis, however, contains a rich network of capillaries and is where the drug can diffuse into the bloodstream. The subcutaneous tissue sits below the dermis, outside the skin layers, so the layer within the skin where systemic entry occurs is the dermis.

Systemic absorption requires the drug to reach the skin’s blood vessels. The stratum corneum is the main barrier to crossing the skin, and the epidermis itself is largely avascular. The dermis, however, contains a rich network of capillaries and is where the drug can diffuse into the bloodstream. The subcutaneous tissue sits below the dermis, outside the skin layers, so the layer within the skin where systemic entry occurs is the dermis.

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